Accreditation Statement: Howard University College of Pharmacy is accredited by the Accreditation Council for Pharmacy Education as a provider of continuing pharmacy education.
- Examine the following pharmacokinetic and pharmacodynamic terminology as pertains to theophylline: Therapeutic range, half-life clearance, volume of distribution, and biovaliability.
- Distinguish a drug sample appropriate time to sample theophylline following: An oral dose and An intravenous dose
- Calculate a Vd and loading dose of theophylline considering the following factors: a. Weight; b. Ideal body weight; C. Renal function; and d. Desired plasma concentration
- Analyze what factors (drugs and disease states) may be associated with an altered clearance of theophylline.
- Calculate a CL theophylline and maintenance dose to achieve Cpssmax, Cpssave, Cpssmin from: a. Usual literature value and patient's clinical history b. A known theophylline dosing history and a measured theophylline concentration
- Calculate an expected theophylline concentration given the dosing history and the time of sampling.
Dr. Krishna Kumar, PhD
- Illustrate the kinetics of oral absorption of drugs
- Compare and contrast the kinetics of oral versus IV absorption.
- Define absolute and relative bioavailabilities
- Distinguish plasma kinetics vs. urinary kinetics.
- Analyze the Bioequivalence concept.
Dr. Pradeep K. Karla